Heme proteins: Hemoglobin

Bacillus anthracis Secretes Proteins That Mediate Heme Acquisition from Hemoglobin

Acquisition of iron is necessary for the replication of nearly all bacterial pathogens; however, iron of vertebrate hosts is mostly sequestered by heme and bound to hemoglobin within red blood cells. In Bacillus anthracis, the spore-forming agent of anthrax, the mechanisms of iron scavenging from hemoglobin are unknown. We report here that B. anthracis secretes IsdX1 and IsdX2, two NEAT domain ...

Heme, Myoglobin, Hemoglobin

The Heme-globin Linkage of Hemoglobin

It was recently reported that CO hemoglobin is relatively more resistant than oxyhemoglobin to digestion by the pancreatic enzymes (l), and that a heme-protein fragment can be precipitated either from the digest solution or from the dialyzed digest by acidification with acetic acid (2). The composition of this CO product has now been investigated. Iron Content-The value of the iron to nitrogen ...

Exchange of heme among hemoglobin molecules.

Heme-Spin Label Studies of Hemoglobin

In order to investigate the protein conformation in the vicinity of the heme and the spin states of the heme-iron in dissolved hemoglobins, a nitroxide spin label was covalently attached to one of the propionic acid groups of the porphyrin ring. The optical spectra of the heme-spin labeled ferrihemoglobins were identical to those of native hemoglobins indicating that the spin labeling did not a...